Collagenase

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  Neutral Protease NB GMP Grade
  SERVA Electrophoresis GmbH, µ¶ÀÏ

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- EU-Guideline¿¡ ºÎÇÕÇÏ´Â Good Manufacturing Practice (GMP for active pharmaceutical ingredients) ½Ã¼³¿¡¼­ Á¦Á¶µÈ ¼¼°è ÃÖÃÊÀÇ Collagenase

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Pack Size

Collagenase NB 1 Premium Grade from C. histolyticum

• Isolation of pancreatic islets

• Use in combination with Neutral Protease NB

17455.03

2,000 PZ*-U

Collagenase NB 1 GMP Grade from C. histolyticum

• Isolation of pancreatic islets for transplantation into humans

• Use in combination with Neutral Protease NB GMP Grade

17452.01   

2,000 PZ-U

Collagenase NB 4 Standard Grade from C. histolyticum

• Isolation of various cell typeshepatocytes, cardiomyocytes, pancreatic islets, nerve and endothelial cells, chondrocytes,tumor cells and others

17454.02 17454.01

500 mg1 g

Collagenase NB 4G Proved Grade from C. histolyticum

• Isolation of various cell types

– especially adipocytes, ?broblasts, hepatocytes, frogoocytes(protocol available)

17465.01 17465.02 

500 mg1 g

Collagenase NB 5 Sterile Grade from C. histolyticum

• Application ?elds see Collagenase NB 4

• Sterile and thus ready to use

17459.01 17459.03

1 g (bag)1 g (vial)

Collagenase NB 6 GMP Grade from C. histolyticum

• Application ?elds see Collagenase NB 4

• Production of cells or tissue engineering for transplantation into humans

17458.01 17458.03 

1 g (bag)1 g (vial)

Collagenase NB 8 Broad Range from C. histolyticum

• Isolation of cardiomyocytes, hepatocytes, pancreatic islets, chondrocytes and others from bigger animals and humans

17456.01 17456.02

250 mg1 g

Neutral Protease NB from C. histolyticum

• Use in combination with Collagenase NB 1 or Collagenase NB 8

30301.11 30301.12

50 DMC-U100 DMC-U

Neutral Protease NB GMP Grade from C. histolyticum

• Use in combination with Collagenase NB 1 GMP Grade

30303.01

100 DMC-U

*PZ activity according to Wunsch, measured at 25oCSERVA Collagenase NB is not intended for use in humans. Responsibility for use of these enzymes in clinical applications and the methods to isolate, purify, cultivate and transplant cells lies solely with the providing physician/researcher.

 

qCollagenase Qualities

 

*   Isolation of Various Cell Types

*   Optimal tissue dissociation using collagenase with a balanced ration of other proteolytic activities:

Collagenase NB 4 Standard Grade

Collagenase NB 4G Proved Grade

Collagenase NB 5 Sterile Grade

Collagenase NB 6 GMP Grade

*   Mild and effective- Collagenase NB 4 Standard Grade for optimal isolation of a broad variety cells.

*   Function tested- Collagenase NB 4G Proved Grade is especially suitable isolation of adipocytes, fibroblasts, hepatocytes and frog oocytes (protocol is available).

*   Ready to use- Collagenase NB 5 Sterile Grade is produced aseptically according to the European Pharmacopoeia.

 

qProduction Compliant to GMP

*   Good Manufacturing Practice for Cell Isolation

Production of cells or tissue engineering for transplantation into humans require quality standards according to GMP-guidelines:

Collagenase NB 1 GMP Grade

Neutral Protease NB GMP Grade

Collagenase NB 6 GMP Grade

These enzymes are critical raw materials and thus manufactured in compliance with the EU-Guide to Good Manufacturing Practice ¡°GMP for active pharmaceutical ingredients¡± and with the European Pharmacopoeial requirements for reagents used in cell production.For incoming components inspection according to GMP, Reference Collagenase are offeredby SERVA.

 

All Collagenase NB qualities are manufactured at the pharmaceutical plant of Nordmark Arzneimittel GmbH & Co. KG in Uetersen, Germany, the world largest manufacturer of collagenase. The high quality standards of Collagenase NB production quarantee excellent lot-to-lot consistency.

 

qData sheet

*  Datasheet_CollagenaseNB1.pdf

*  Datasheet_CollagenaseNB1_GMP.pdf

*  Datasheet_CollagenaseNB4G.pdf

*  Datasheet_CollagenaseNB5.pdf

*  Datasheet_CollagenaseNB6_GMP.pdf

*  Datasheet_CollagenaseNB8.pdf

*  Datasheet_NeutralProteaseNB.pdf

*  Datasheet_NeutralProteaseNB_GMP.pdf

*  TechnicalNotes_CollNB.pdf 

qProtocol

*  Protocol_adipocytes_pre_human.pdf

*  Protocol_Cardiomyocyte-isolation_rat.pdf

*  Protocol_Islet-isolation_human_GMP.pdf

*  Protocol_Islet-isolation_humanNB1.pdf

*  Protocol_Islet-isolation_rodent.pdf

*  Protocol_NB6_adipocytes_adult_human.pdf

* Roboocyte_OocytePreparation.pdf